Traffic in the area was backed up to Fry Road as crews worked to clear the 18-wheeler crash that happened just after 5 a.m Wednesday, HPD said.
Police said the driver of the cement truck was driving along Schurmier Road and "disregarded a stop sign," hitting a Toyota Corolla that was heading northbound on Cullen Blvd. An investigation continues into the crash.
Police said a mother was stopped on the shoulder due to a blown tire when another driver, possibly intoxicated, crashed into her, injuring her 5-year-old and killing her 3-year-old.
Police said a 16-year-old driver was taken into custody and is being charged with failure to stop and render aid.
Houston police are investigating two separate crashes on the IH-610 West Loop, where a pedestrian was killed and a woman drove into the wall.
According to police, the pedestrian was run over several times. Only one of several drivers thought they hit an animal and returned to the scene.