Orange County coroner's officials say John Selner of Fort Worth died of natural causes during the flight Tuesday morning.
The Orange County Register says the man was on American Airlines Flight 2249 when the crew notified John Wayne Airport that they had a medical emergency. They also performed CPR.
The flight landed shortly after 11:30 a.m. Orange County fire Capt. Steve Concialdi says paramedics worked on the man but he was pronounced dead about 10 minutes after the landing.