Events range from a kids' 1-K run to a 10-K race.
The races begin at 5:30pm on Galveston's East End, and finish at Saengerfest Park at the corner of 23rd and Strand.
Clay Wade, Galveston Historical Foundation's director of events, says the race is USA Track and Field-certified. The route will highlight the island's tree sculptures, carved from 100-year-old trees destroyed by Hurricane Ike, along with Galveston monuments and architecture.
"Beginning and ending at the Mardi Gras arch, this year's race will feature new race management and a fun-filled party following the race at Saengerfest Park with entertainment, food and drink for the entire family," Wade said in a release.
Prices for the races range from $25 to $45 with proceeds benefiting the Galveston Historical Foundation. Each registrant also receives a free ticket to the 39th annual Dickens on the Strand festival.
For more information, visit the foundation's website.