Knox family spokesman Dave Marriott says Robert Barnett will represent Knox in discussions with publishers and help her evaluate other opportunities.
Barnett has represented the literary interests of U.S. Presidents Barack Obama, Bill Clinton and George W. Bush, as well as former British Prime Minister Tony Blair and former Alaska Gov. Sarah Palin.
Knox returned to her hometown of Seattle in October after she was cleared in Meredith Kercher's death.
The 24-year-old had been in custody since 2007, and experts have suggested she could score a seven-figure book deal. She hasn't granted any interviews since her release.