It will be his 16th time as host. The "30 Rock" actor moves past Steve Martin, who has done it 15 times. Radiohead will be the musical guest, the network said Friday.
Melissa McCarthy of CBS' "Mike & Molly" and the movie "Bridesmaids" will be the host of the show's second week, her "SNL" debut. The country trio Lady Antebellum will be her musical guest.