Police Director Toney Armstrong says Officer Timothy Warren, a patrol officer, died at Regional Medical Center after the shooting.
Warren was among several officers responding to a call at the Doubletree Hotel around 7 p.m. Sunday. A civilian victim, who hasn't been positively identified, was also shot and pronounced dead at the scene in what officials say started as a domestic dispute.
WMC-TV reported that police had responded earlier in the night to a disturbance call involving the same suspect, but let him go.