San Augustine County is just east of Lufkin.
The San Augustine Sheriff's Office told ABC13 multiple homes and businesses were damaged or destroyed including a Family Dollar.
So far, no major injuries or deaths have been reported.
The worst of the damage is along the west side of San Augustine, where power lines are reported down everywhere.
Schools in the area are closed Thursday.
It appears a large, violent tornado touched down in San Augustine, TX, which is about 40 miles ENE of Lufkin. Reports of damage coming in. Hopefully everyone is okay.— Travis Herzog (@TravisABC13) April 25, 2019
This same storm system also caused serious damage near the campus of Louisiana Tech University in Ruston, Louisiana, between Shreveport and Monroe.
Two people in Ruston were killed, Louisiana governor John Bel Edwards said.
Wednesday afternoon, a tornado touched down in Bryan sending storm debris flying into the air.
FULL STORY: Tornado touches down in Bryan, sending debris in the air