Keflezighi is a former New York City Marathon champion and Olympic medalist. He ran the 26.2 miles from Hopkinton to the finish on Boylston Street in Boston's Back Bay on Monday in 2 hours, 8 minutes, 37 seconds.
Keflezighi held off Wilson Chebet of Kenya who finished 11 seconds behind. The 38-year-old from San Diego looked over his shoulder several times over the final mile. After realizing he wouldn't be caught, he raised his sunglasses, began pumping his right fist and made the sign of the cross.
No U.S. runner had won the race since Lisa Larsen-Weidenbach took the women's title in 1985; the last American man to win was Greg Meyer in 1983.