Sheen was famously fired from his sitcom "Two and a Half Men" after a very public meltdown during which he claimed to be a "rock star from Mars" who has "tiger blood" and "Adonis DNA."
The 46-year-old actor is the subject of the latest roast, which was taped Saturday night at Sony Studios and will air Sept. 19.
Sheen smiled and laughed as roasters jabbed at his famous family, his notorious taste for drugs and prostitutes and his primetime firing.
"How much (cocaine) can Charlie Sheen do?" cracked one comic. "Enough to kill two and a half men."