A pickup truck carrying three men was westbound on Beaumont Highway. The driver tried to turn left into a parking lot, but he pulled in front of an 18-wheeler, officials said.
The 18-wheeler slammed into the side of the pickup truck.
One of the men was riding in the back bed of the truck. He was thrown from the vehicle and airlifted to an area hospital in serious condition.
The two other men were also taken to the hospital. At last check, both were stable.
The driver of the big rig was not hurt.