The ceremony, to be held at the Nokia Theatre L.A. Live in Los Angeles on July 20, will be televised live on ESPN, the network said Wednesday.
Timberlake says he's a sports junkie.
"I'll do my best to deliver a great show, as I do not want to be roughed up backstage by these athletes who are bigger, faster and stronger than me," he said.
Timberlake will be in the summertime movie, "The Love Guru," with Mike Myers and Jessica Alba. He recently showed a different kind of stage presence when he inducted Madonna into the Rock and Roll Hall of Fame.