Knight's resignation was first reported by the Lubbock Avalanche-Journal. Chris Cook, a spokesman for Myers, confirmed the resignation.
Knight has 902 career wins, more than any coach in the history of Division I men's basketball. Win No. 900 came last month against Texas A&M.
The 67-year-old Knight has been a head coach for 42 years at three Division I schools. He got his 100th victory at Army, then moved to Indiana, where his Hoosiers went 662-239 and won three national championships from 1971-2000.
His first NCAA title came in 1976 when Indiana went undefeated, a feat no team has done since. In 1984, he coached the U.S. Olympic team to a gold medal in Los Angeles.
Knight, known as much for his fiery temper as his coaching brilliance, came to Texas Tech in March 2001, six months after being fired by Indiana for what school officials there called a "pattern of unacceptable behavior."
He began his coaching career in 1965 at Army, where at 24 he was the youngest-ever Division I coach.
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