Derek Johnson led Prairie View (2-13, 0-3) with 15 points, including a 3-pointer that pulled the Panthers within 64-63 with 26 seconds left before the Tigers clinched the game at the free-throw line.
Brian Ezeh had 14 points for the Panthers, and Jacolby Satterwhite had 12 points and team highs of five steals and three assists.
Texas Southern led 58-49 after a 3-pointer by Miller with 3:54 left, but Prairie View went on a 9-2 run to get within 62-60 at the 1:18 mark. On their next possession, the Panthers missed a layup that would have tied it and a 3-pointer that would have put them ahead.
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