It happened around 1:15pm in the 3600 block of Bloomfield near Rosehaven.
When police arrived at the scene, the victim was already dead.
Officials have no suspects in custody. According to police, two young children were in the house at the time of the shooting, but it was unclear if anyone else was home at the time.
Investigators said this could be a drug-related incident.
Anyone with information can call Crime Stoppers at 713-222-TIPS.