The accident happened around 10:15pm Saturday in the 18900 block of Shay Lane at Springlea in northeast Harris County.
Officials said 51-year-old Anthony Ray Miller and his wife, Karen, were driving through a neighborhood in Humble when they got into some sort of argument.
According to deputies, Karen Miller jumped out of the passenger seat of their moving pickup truck – a large Chevrolet Silverado dually – and was run over by the rear tires.
She died at the scene. They were only a couple blocks away from home.
Anthony Miller was arrested and charged with driving while intoxicated. Bond was set at $500.
Deputies said this case remains under investigation.