Big Papi added another highlight to his resurgent season with a relentless series of drives into the elevated stands above the right-field wall.
Ortiz hit 21 homers in the first two rounds of his fourth derby before holding off Ramirez and beating a field missing most of the majors' top power hitters.
Ramirez matched Ortiz's 21 homers in the first two rounds, pulling most of his shots over the left-field wall. But Ortiz became just the second slugger to reach double digits in the final round, while Ramirez managed only five.