Yesterday would have been Joplin's 65th birthday. She died in 1970 from a drug overdose.
Joplin was 4 years old when her family moved into the home that now has the marker. Her first childhood home was torn down in 1980.
Alicia and David Sanchez and their 8-year-old son now live in the house. As they helped pull a Texas flag off the marker, the crowd applauded, with some shouting, "We love you Janis."
Alicia Sanchez says that even though the Joplins moved out in 1975, many fans still drop by.
She doesn't let strangers inside, but said she doesn't mind people taking pictures in the front yard.