"The cause of death is unknown and is being investigated by host nation authorities in cooperation with U.S. Navy," a Navy statement said.
The sailors, whose identities weren't immediately released, were stationed aboard the USS Fort McHenry, which is on a seven-month voyage through the Gulf of Guinea aimed in part at training local militaries on maritime security.
They were found dead in their room at a hotel in Tema, where they had taken time off during the mission, the Navy said in a statement.