Jackson threw four touchdown passes, ran for 86 yards and helped the Baltimore Ravens roll to their sixth straight victory, 41-7 over the Houston Texans on Sunday.
The game was billed as a matchup between first-place AFC teams and two of the best double-threat quarterbacks in the NFL.
Jackson and the Baltimore defense made it a one-sided affair, and now the Ravens (8-2) are riding their longest winning streak since a seven-game run in 2000, their first Super Bowl season.
After throwing three touchdown passes to put Baltimore up 21-0 in the third quarter, Jackson followed with his most impressive play of the day: a 39-yard run in which he broke six tackles, weaving through the Houston secondary as if playing keep-away with the football.
Watson, on the other hand, spent the entire afternoon running from a defense that utilized a variety of blitzes and coverages. Baltimore rang up seven sacks -- six against Watson -- forced two turnovers and limited the nimble-footed quarterback to 12 yards rushing on three carries.
Watson went 18 for 29 for 169 yards with a lost fumble and an interception. Houston (6-4) fell behind 34-0 before Carlos Hyde ran for a 41-yard touchdown with 7:10 remaining.
Jackson remained on the sideline after that. With Robert Griffin III taking the snaps, Gus Edwards scored on a 63-yard run with 4:10 left.
And with that, Watson was removed from the game, too.
Jackson completed 17 of 24 passes for 222 yards. After starting 1 for 6, he completed 13 in a row to turn the game into a rout.
Mark Ingram caught touchdown passes of 25 and 12 yards in the second half after Seth Roberts and Mark Andrews scored before halftime.
For the season, Jackson has 19 TD passes, five interceptions and a whopping 788 yards rushing.
Houston came in with four wins in five games before last week's bye. The extra rest obviously was of no use in preparing for a strong Ravens team that defeated Seattle and New England during this impressive winning streak.
The Texans failed to score in the first half for the first time this season, generating only 102 yards of offense and yielding four sacks while falling behind 14-0.
Watson lost a fumble on Houston's opening drive, but Baltimore's Justin Tucker subsequently hit the right upright with a 43-yard field goal try. It was his first miss in 23 attempts dating to last season.
Later in the quarter, the Ravens were denied a first down on a fake field goal.
Jackson found his groove on Baltimore's third possession, throwing for 50 yards and running for 12 during a 90-yard march that ended with a 15-yard touchdown pass to Roberts.
For an encore, Jackson threw an 18-yard scoring strike to Andrews to cap a 70-yard drive and make it 14-0 with 2:14 left in the first half.
With four catches in the first quarter, the 27-year-old Hopkins became the second-youngest player in NFL history to reach 600 receptions for his career. Only Larry Fitzgerald was quicker to 600.
Texans: S Mike Adams received a concussion during pregame warmups and did not play. ... CB Lonnie Johnson Jr. hurt his right foot during Jackson's 39-yard jaunt. ... S Justin Reed left in the third quarter with a shoulder injury. ... WR Will Fuller (hamstring) was inactive.
Ravens: DT Michael Pierce (ankle) was inactive.
Houston makes a quick turnaround, hosting Indianapolis on Thursday night in a key AFC South matchup.
Baltimore travels across the country to face the Los Angeles Rams on Monday night.
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Ingram makes a man miss for his 2nd TD of the game
Mark Ingram catches a short pass, ducks under a tackler and dives into the end zone for his second score of the game.