Along Interstate 10, the famed Buc-ee's travel stop was already busy with travelers, some of whom are headed out to celebrate with families.
"I'm not too concerned," one traveler said. "I just wear my mask and stay as safe as possible."
The agency recommends that Americans celebrate the holiday at home with the people they live with, as gathering with family and friends from outside of the household can increase the chances of getting or spreading COVID-19 or the flu.
These new guidelines come one day after the United States marked the grim milestone of a quarter-million COVID-19 deaths. The CDC now estimates between 276,000 and 298,000 deaths by Dec. 12.
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"I'm trying to be as safe as possible," another traveler told ABC13's TJ Parker, who asked about plans for the week and who they'll spend the holidays with. "A few of my friends, five or six. We've practiced social distancing from the get-go."
Dr. Henry Walke, the CDC's COVID-19 incident manager, said there's a risk of gathering with loved ones that may live in close proximity.
"These times are tough. It's been a long ... almost 11 months now, and people are tired. And we understand that, and people want to see their relatives and their friends. And the way they've always done it. But this year, particularly, we're asking people to be as safe as possible, and limit their travel," Walke said.
Dr. Fauci warns Thanksgiving gatherings pose high risk for COVID-19
If people do travel or gather with other households, the CDC urges them to continue to follow the guidance to wash hands frequently, wear masks when around people outside your household, and try to have the Thanksgiving meal outside or with windows open.
SEE MORE: CDC updates Thanksgiving guidance, recommends that Americans do not travel
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