The famous graffiti was spotted Wednesday morning on the railroad bridge over I-10 and I-45 north of downtown.
The graffiti saw a lot of change in 2020.
The sign was painted over when the coronavirus pandemic first began in March 2020 to say "Wash Ur Hands."
The sign briefly returned to its original state before it was changed again to say "George Floyd" in June 2020 after the Houston-native was murdered by police officer Derek Chauvin in Minneapolis, Minnesota during an arrest.
After that, the sign was changed to read "#SaveOurChildren" in August 2020. The phrase began as a noble awareness campaign to combat human trafficking, but was thrust into controversy by conspiracy theorists who allege that children are being abducted in large numbers to supply a child trafficking ring.
Finally, ahead of the 2020 Presidential Election, the sign was painted over with the phrase "Vote or Die."
Since then, the Houston landmark had not been restored to its original state.
In the past, the person behind the art spoke anonymously with ABC13.
RELATED: 'Be Someone' artist speaks about famous statement
"I get it. It's vandalism, but it's in a different sense, too, if you just take those words and apply it to yourself, it might mean something to you," he told ABC13 in 2016.
Though it's considered a tourist attraction by some, it's still graffiti. The message adorns a railroad bridge owned by Union Pacific Railroad.
Union Pacific officials have discouraged the graffiti in the past due to property damage and dangers around trains.
"Often, by the time a trespasser hears the train, it's too late," railroad officials said in a statement.