The California Highway Patrol says officers noticed signs of possible intoxication when they helped move the 43-year-old actress' stalled car off Interstate 5 in Burbank late Saturday.
The CHP said that after an investigation, officers arrested and booked her on suspicion of DUI. Kelly was released on $5,000 bail.
An email to her agent was not immediately returned.
It was not her first brush with the law. Kelly and her husband Robert Joseph Gilliam were arrested last November in connection to a disturbance at their home in the Charlotte, N.C., suburb of Mooresville.
Kelly portrayed Laurie Forman, sister of Topher Grace's lead character Eric, on the FOX series, which ended in 2006.
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