The fire started right around 1pm Thursday in the home near the intersection of Wilmette and Ashwood, burning through the roof of the house.
A man is dead and a woman who investigators believe to be a relative has been rushed to the hospital. There's no word at this point on the extent of her injuries.
Investigators are working inside the home to determine what sparked the deadly fire. The fire appears to have begun in the attic or roof area.
According to a Sheldon fire chief, a neighbor from across the street called 911 after seeing thick black smoke coming from the roof. When firefighters first arrived, they couldn't enter the home due to the thick smoke.
A man and woman were both inside the home. Investigators say the man was trapped in the back bedroom.
"He is bedridden and she was trying to pull him out when the fire started," said neighbor Joshua Garland. "But she wasn't able to get him out. The smoke was too thick, so she had to get out of the house."
There is no word on the extent of the woman's injuries. The victims' identities have not been released.