The accident happened around 6:30pm on the Gulf Freeway northbound at F.M. 517 in Dickinson.
Police said a 27-year-old woman with an infant passenger was driving a Ford F-150 pickup truck recklessly when she lost control and struck the inside retaining wall.
The truck then went all the way across the northbound lanes and hit the outside retaining wall, striking a motorcycle in its path.
All lanes were closed while LifeFlight airlifted two riders from the motorcycle to an area hospital.
A privately-owned PHI, Inc. medical chopper responded to airlift the patients from the truck, but they ended up being taken via ambulance.
The PHI helicopter was stalled on the freeway due to mechanical difficulties. The chopper was eventually repaired and it departed around 8:40pm.
Traffic was backed up for about four miles when the lanes reopened at 9pm.
The conditions of the four patients were not available late Sunday, but police said none of the injuries were life-threatening.
If you're traveling this holiday weekend, you can check traffic conditions and Transtar Jam Cams anytime on our abc13.com Traffic page.
