The magazine says "Family Guy" DVDs and merchandise have earned a reported $1 billion. MacFarlane is the highest-paid writer on TV, with a "Family Guy" spinoff called "The Cleveland Show" in the works.
Says Entertainment Weekly: "That frat-boy persona is only a cover."
"30 Rock" creator and Sarah Palin imitator Tina Fey is second on the magazine's list. CBS Paramount Network Entertainment chief Nancy Tellem is third. Oprah Winfrey came in sixth.
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