The R&B singer and White Stripes frontman have teamed up for "Another Way to Die," the first duet to be chosen as a Bond theme.
Producers said White has written and produced the song and also plays drums, as well as singing with 11-time Grammy winner Keys.
Producers Michael Wilson and Barbara Broccoli said they were "delighted and pleased to have two such exciting artists as Jack and Alicia, who were inspired by our film to join together their extraordinary talents in creating a unique sound for 'Quantum of Solace."'
Previous Bond themes have been performed by the likes of Paul McCartney, Duran Duran and Madonna, and each new film's tune always produces intense speculation.
Troubled diva Amy Winehouse had previously been linked to the "Quantum of Solace" theme. But her collaborator Mark Ronson said earlier this year that work on a song for the film had been abandoned because Winehouse was not ready to record.
Other reports had suggested singers Duffy and Leona Lewis were being considered.
"Quantum of Solace" sees Daniel Craig return as suave secret agent 007. It is due for release in Britain on Oct. 31 and around the world in November.
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