Esparza won her third U.S. title in a row, defeating Melissa McMorow of San Francisco at 106 pounds by a score of 26-7.
Villapondo defeated Samantha Guzman, Oak Park, Ill., 29-27, for her first national title at 101 pounds.
Both Esparza and Villapondo train in Houston at the Elite Boxing Gym under coach Rudy Silva.
- Send us your sports story tips
- Click here for more sports stories