It happened on Milam and Anita in Midtown around 2 a.m.
The patrol officer heard gunfire and rushed to the scene of the shooting, HPD said.
That's when he saw a vehicle trying to leave and found the four men shot inside.
The conditions of the victims weren't immediately known.
Update from investigators: despite preliminary information to the contrary, one of the males has not died. However, he does remain hospitalized. The investigation is continuing. #hounews https://t.co/2eQT58kfoW— Houston Police (@houstonpolice) May 23, 2020