Mississippi State (7-6) wrapped up its fourth straight winning season and prevented Rice (10-4) from winning bowl games in back-to-back years for the first time. By accounting for five touchdowns, Prescott set a Liberty Bowl record.
After falling behind 7-0, the Bulldogs scored touchdowns on four consecutive possessions.
Mississippi State's Jameon Lewis caught nine passes for 220 yards to break the Liberty Bowl receiving record held by Houston's Vincent Marshall, who had 201 yards in a 44-36 loss to South Carolina in 2006. Lewis also set the school single-game record.
Prescott was 17 of 28 for 283 yards and also ran for 78 yards on 14 carries.
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