Organizers say Gibb will attend the Royal Philharmonic's premiere performance of "The Titanic Requiem" in London on April 10, and will perform a new song, "Don't Cry Alone."
The classical composition commemorates the April 1912 sinking of the ocean liner and the loss of more than 1,500 lives.
The 62-year-old Gibb was hospitalized late last year for stomach and colon problems, but told the BBC last month he was making a good recovery. He did not disclose the nature of his illness but said a growth on his colon had been removed.
The Bee Gees had a string of hits in the disco era, including "Stayin' Alive."
