The Twitter feed dubbed "Angie's Right Leg" has more than 12,000 followers by midday Monday.
Most of what Jolie's leg has to say is fairly simple-minded. Sample tweets include "I'm a leg!" and "Look at the leg!"
At the Oscars, Jolie's glamorous black dress featured a split by her right leg. She appeared to accentuate it while presenting the award for best adapted screenplay.
One of the winners of that category, "The Descendants" co-writer Jim Rash, mocked the pose while accepting his award.