Muonelo flapped his arms to encourage Oklahoma State's largest home crowd of the season, while Knight slowly entered his team's huddle on the opposite sideline.
The Cowboys (10-5, 1-0 Big 12) scored the next six points and held Texas Tech (9-6, 0-1) scoreless for another 4 minutes after the timeout to extend a 21-2 run and build a 67-41 lead.
Freshman Ibrahima Thomas added a career-high 16 points and Anderson ended up with 13 after taking a hard fall on a fast break in the first 3 minutes of the game. Marcus Dove scored 10 points.
Martin Zeno scored 10 points and Esmir Rizvic had nine points and a career-high 12 rebounds for the Red Raiders, who got ahead early by controlling the boards and getting to the free throw line.
Knight was seeking to become only the third Division I coach with 900 career wins, and the first in the men's game. Tennessee women's coach Pat Summitt has won 959 games, and former Texas women's coach Jody Conradt won exactly 900 before retiring last season.
Knight's next chance at No. 900 comes Wednesday night, when the Red Raiders host No. 11 Texas A&M.
Rizvic had 10 rebounds in the opening half, and his layup started an 18-5 run that gave Tech a 24-16 lead. Oklahoma State responded immediately by reeling off nine straight points to get back in the game and was up 35-32 at halftime.
The Cowboys turned the tide by crashing the boards and avoiding the ticky-tack fouls that sent Texas Tech to the line 16 times in the opening half.
And then Muonelo got hot.
The sophomore who missed all of Big 12 regular season play last season after leg surgery hit his first five 3-pointers and seven of his first eight shots. He got a standing ovation from the crowd he was replaced in the final 3 minutes with Oklahoma State leading by 21.
One game after drawing his first technical foul in over a year, Knight sat calmly on the Red Raiders' bench for most of the game.
He drew an early "Sit down! Shut up!" chant from the crowd as he spoke to an official after Tech's John Roberson undercut Anderson, the Cowboys' leading scorer, on a fast-break chance less than 3 minutes into the game.
He watched in disgust as Tech let the shot clock expire shortly after his timeout, and walked to halfcourt to shake the hand of Cowboys coach Sean Sutton after the game.
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