One person is dead after a crash involving an 18-wheeler and another vehicle on Wednesday, according to Houston Police Department.
Just before noon, TranStar cameras showed the crash had blocked all but one lane, leaving a single lane for traffic to get by.
The closure will be between Polk and Clay streets through Oct. 31.
An 18-wheeler crash led to heavy delays for drivers along SH-25 westbound in the Pasadena area for hours Friday morning.
All eastbound lanes along the South Loop near Telephone Road are shut down due to the major crash and spill, according to TranStar.
The Houston Police Department said the load was reported just after 7 a.m on Monday. It is unclear what the load contains.