Police said the crash happened in the area of Almeda and Reed around 3:45 p.m., not too far from Highway 288.
SkyEye overhead captured at least five vehicles left in wreckage. One of the vehicles appeared to have plowed into a sign of a nearby business.
Police added one driver at the scene showed signs of intoxication.
HPD did not immediately say whether anyone was arrested.
Houston police have had to deal with recent traffic deaths possibly involving intoxicated drivers.
On Sunday night, a person was killed on the Southwest Freeway after a driver slammed into another vehicle.
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