Knight played Dr. George O'Malley on the hospital drama. In the season finale that aired in May, George had been severely injured in an accident and appeared to be at death's door -- or beyond.
Knight's role on "Grey's Anatomy" had been diminished this season and the actor had asked to be let out of a contract that still had three years left to go.
In a statement, Knight said the decision to leave wasn't easy and said he'd miss his fellow cast members and the show's crew. He also thanked fans for their enthusiastic support.
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