Seven Americans and two citizens of Sweden are among the injured, according to Quintana Roo state Civil Defense spokesman Vicente Martin, who said authorities haven't yet established the nationalities of the dead.
Video images from the scene showed the bus on its side in vegetation off the two-lane highway, with some survivors lying on the pavement while others walked around.
Martin said the crash occurred as the bus was on its way to the ruins at Chacchoben, about 110 miles (175 kilometers) south of Tulum.
The cause of the accident was under investigation.
Costa Maya Mahahual, the bus company involved, said in a statement that the bus was carrying tourists who had arrived to the coastal town of Mahahual aboard a cruise ship.
In addition to the tourists, a guide and driver were aboard the bus, the company said.
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