It happened around 4:30am on Martin Luther King Jr. Boulevard at Bungalow Lane.
Police said the man was southbound on MLK when he lost control of his pickup truck.
The driver veered to the right and went over a curb and a sidewalk before he hit a fence, police said.
According to investigators, he got back on MLK southbound but then crossed the median and drove into the northbound lanes.
The driver ended up crashing into a Hummer parked in a driveway. He was dead when officers arrived.
The cause of the crash is under investigation. The man's identity has not been released.