The three-day ride begins Thursday. This is the second year for Bush to host the Warrior 100K. Last year, the ride was held in the Big Bend region of West Texas.
In a statement, Bush says the ride is a reminder of the "unbelievable courage, skill and sacrifice of those who wear the uniform of the United States."
Twenty military members are participating in the ride, which is part of the George W. Bush Institute's Military Service Initiative. The institute is part of the George W. Bush Presidential Center being built in Dallas.
The state park is 20 miles southeast of Amarillo.