After striking out looking and grounding out in his first two at-bats, Rendon hit a two-run home run in the fourth inning, a three-run homer in the seventh and another two-run shot in the eighth.
He had seven RBIs and set a record for home runs by one player in a game at UFCU Disch-Falk Field.
Every Rice (39-22) starter recorded at least one hit and one run.
The loss eliminated Rider (36-23) from the Austin regional after the Broncs were outscored 30-1 in their two games.