It will be the German-born Benedict's third visit to a synagogue as pope after ones in Cologne, Germany, and New York.
Rome's chief rabbi Riccardo Di Segni says the visit will be "an example of how to coexist even if we have differences."
Some Jews and historians have argued that Pius was largely silent on the Holocaust. The Vatican insists Pius used quiet diplomacy to try to save Jews and that speaking out more forcefully would have resulted in more deaths.