The crash occurred around 3 a.m. Tuesday at the intersection of Haverford and Overbook avenues.
Police say a man and a pregnant woman in a pickup truck were stopped at a traffic light when they were rear-ended by a white Lexus.
Following the impact of the crash, officials say the woman went into premature labor.
When medics arrived on the scene, they helped deliver the baby inside the cab of the truck.
Both the mother and the baby were taken to the hospital. Action News is told the baby was due in May.
There is no word if the man in the truck was injured.
The striking vehicle overturned onto its roof at the scene.
The Lexus driver was arrested for DUI and driving with a suspended license. A female passenger was also in the vehicle. It's not clear if she suffered any injuries.
The investigation lead to the closure of Haverford Avenue.