The gruesome injury suffered by their center overshadowed everything else Monday night.
"Devastating," Blazers coach Terry Stotts said.
Nurkic had 32 points and 16 rebounds before suffering his left leg injury in the second overtime, and the Blazers outlasted the Brooklyn Nets 148-144.
"It made me sick to my stomach," Blazers guard Damian Lillard said of Nurkic's injury. "As I was walking over there, I saw everyone else turn around real quick and walk away, and then I look and I saw his leg."
Nurkic was hurt when his leg bent awkwardly as he battled for an offensive rebound. His leg was immobilized and he was removed on a stretcher while surrounded by members of both teams. Nurkic was then transferred to a local hospital and the team said he sustained compound fractures to his left tibia and fibula.
After the injury, Blazers made enough plays to get the win, but then reality hit.
"He wouldn't want us to say, 'All right, let's feel sorry for ourselves and feel sorry for Nurk and not care as much,'" Lillard said. "So we're going to finish the job, try to get the game, but I think after the game, that's when it kicks in."
The Blazers held a collective moment of silence and prayer for Nurkic in the locker room following the game.
"I'm just going to go home and pray for him," Blazers center Enes Kanter said. "This is bigger than basketball. We clinched the playoff spot but we can't even celebrate. He was a big part of our family. Not our team, our family."
The Nets, who watched guard Caris LeVert wheeled off the court after an injury earlier this season, had the same concern for Nurkic.
"That's what our guys are talking about in the locker room," Nets coach Kenny Atkinson said." Not the game or the loss. They're talking about a player who was having a great game and a heck of a player so you just pray it's not a long-term thing and he can bounce back. It just takes the wind out of your sails."
The Blazers are already without starting shooting guard CJ McCollum.
"You never want to see that with your friend or your teammate, and then especially as a player, you don't want to see anyone have to go through that and it's also going to be hard on our team," Lillard said. "CJ's already out, now (Nurkic) having a tough injury, so every way you look at it, it was a blow."
Numerous NBA players, as would be expected, quickly expressed sorrow and sent messages of support on social media after seeing the extent of the injury.
"Hate this part of the game. Prayers up for Nurkic!," Miami's Dwyane Wade tweeted.
"Never, never give up, my man Jusuf Nurkic.... I know it's hard ... but you'll come back to play ... I'll wait for you !!!" offered Danilo Gallinari of the Los Angeles Clippers.
Lillard finished with 31 points and 12 assists for Portland, while D'Angelo Russell had 39 points, nine rebounds and eight assists for Brooklyn.
Nurkic's basket made it 134-132 with 3:40 to go into the second overtime. With center Jarrett Allen and Ed Davis having fouled out and the Nets left without a big man, Nurkic had a huge advantage inside whenever he posted up or went for rebounds.
But he was hurt while doing so. After he was taken off the court, Anfernee Simons made two free throws for Portland to put them up 136-132.
A 3-pointer by Rodney Hood extended the lead to 139-132 forced the Nets to start fouling.
There were 12 lead changes and 15 ties over the course of the game, with Portland leading 95-90 after three.
The Nets, however, would storm back in the fourth thanks to the play of their bench. Brooklyn took multiple leads in the final period, with their biggest coming at 112-102 with 6:07 left after a jumper by LeVert.
Portland fought back and with the Nets up one with the ball, Seth Curry stole Russell's dribble and was fouled. He missed the first free throw but made the second to tie the game at 120 with 3.5 seconds left.
Russell missed a deep 3-pointer to force overtime.
Russell scored five early points in the extra period, but Portland took a 128-125 lead on Nurkic's basket before a 3-pointer by Spencer Dinwiddie tied the game again.
It went to a second OT tied at 132 after Russell made a layup and Lillard missed a long final attempt.