This time, the plane forced to make an emergency landing had just left Dallas.
Southwest Airlines said Flight 43 returned to Dallas after there was an indication of a potential performance issue with the plane from the cockpit.
RAW VIDEO: Passengers on board Southwest flight from Dallas to Houston
"Following our established protocol and procedures, the pilots completed a safe landing and the aircraft is being taken out of service for inspection," Southwest said in a statement.
Oxygen masks on board the plane were deployed.
This marks the second time in two days that a Houston-bound Southwest flight was forced to make an emergency landing due to possible pressurization issues.
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Passengers arrived to Houston on another aircraft late Wednesday.