The number of COVID-19 patients in US hospitals Wednesday -- 100,226, according to the COVID Tracking Project -- also is the highest reported on a given day during the pandemic.
One-day death totals can draw from delayed reports across several days. Still, recently soaring daily rates of infections and hospitalizations has various experts predicting the daily death count could regularly surpass 2,000 or 3,000, and perhaps approach 4,000.
The country's daily average of COVID-19 deaths across a week is 1,654 -- above its summer high of around 1,130 but lower than the pandemic peak above 2,240 in late April.
"By this time next week, we are going to be talking about 3,000 deaths a day -- that's 9/11 every single day," Dr. Jonathan Reiner, a cardiologist and professor of medicine at George Washington University, told CNN on Wednesday.
The death count reported Wednesday was 2,804, surpassing the previous one-day high of 2,603 set on April 15, according to Johns Hopkins University data. Earlier, JHU's total for Wednesday was higher -- but that count was corrected Thursday morning because of an error found in one state's tally.
Daily coronavirus cases and hospitalizations also have been soaring -- prompting CDC director Dr. Robert Redfield to say Wednesday that the winter months are likely "going to be the most difficult time in the public health history of this nation."
The 911 emergency call system is "at a breaking point," the American Ambulance Association, which represents all of the nation's ambulance services, said in a letter Wednesday.
"Without additional relief, it seems likely to break, even as we enter the third surge of the virus in the Midwest and West," the letter said.
As for cases: The country's average number of new daily COVID-19 cases across a week was 164,103 Wednesday -- nearly 2.5 times the summertime peak in July.
Los Angeles tells residents to 'cancel everything'
States across the US are racing to catch up with the skyrocketing number of coronavirus hospitalizations.
If the virus continues to spread at its current, unprecedented rate, Los Angeles will run out of hospital beds by Christmas, Mayor Eric Garcetti warned in a Wednesday news conference. He called on residents to "hunker down" and "cancel everything" to help stop the spread.
"The public health condition of our city is as dire as it was in March in the earliest days of this pandemic," he said, adding that the number of daily infections in Los Angeles has tripled since early November and hospitalizations are at a new peak.
In southwestern Kansas, there are no staffed ICU beds available, Gov. Laura Kelly said Wednesday.
"While case numbers may have dipped slightly, the strain on our hospitals and health care workers has not," she said.
Coronavirus hospitalizations in Nevada have been climbing daily since November, with few exceptions, and were at a peak Wednesday with 1,652 people hospitalized, the state's data dashboard showed.
100 million in US could be vaccinated by February
There may still be a ways to go before the wider public has access to a coronavirus vaccine, but developments are moving quickly.
By February, 100 million Americans could be vaccinated against COVID-19, Moncef Slaoui, chief adviser to the federal government's Operation Warp Speed vaccine effort, said Wednesday.
"All the investments we have made in scaling up and starting to stockpile manufacturing of the vaccines allow us to stay confident that we will be able to distribute 20 million vaccines, enough to vaccinate 20 million people in the US in December," Slaoui said in a news briefing.
If Pfizer and Moderna win US Food and Drug Administration emergency use authorization in December, they could distribute 40 million doses of the vaccine by the end of the month, US officials have said. Each vaccine requires two doses, so that's enough to fully vaccinate 20 million people.
Slaoui expected 60 million more vaccines by the end of January, he said.
An FDA panel is expected to meet about whether to authorize the Pfizer and Moderna vaccine candidates on December 10 and December 17, respectively.
Assuming the vaccines are authorized, the first shipments could happen December 15 and 22, respectively, according to an Operation Warp Speed document.
A CDC panel recommended Tuesday that heath care and long-term care workers get inoculated first.
Dr. Paul Offit, a member of the FDA's vaccine advisory group, said Wednesday that technology could help ramp up vaccine production enough to cover the global population.
"You really can, I think, in a couple years, be able to make enough vaccines to vaccinate 7 billion people," he said. "There's no reason to think that couldn't happen."
Vaccine trials for children set for 2021
Though vaccines are on the way, they have only been studied in adults and children older than 12.
Trials for younger children could start early next year, Dr. Francis Collins, the director of the National Institutes of Health, said Wednesday. We "very definitely need to get there," Collins told CNN's Wolf Blitzer.
"We will want to, shortly after the first of the year, also find out: Does this work for younger children, because we know they can be infected and they can pass this along," he said.
"So, that is a next sort of level of test that's going to need to be done in a ... vaccine trial in order to be sure that the vaccine is safe and effective in that group," he said.
"We think it will be, but we want to be sure," Collins said.
As of November 19, the latest data available, nearly 1.2 million children have tested positive for COVID-19 since the pandemic's start. And over just two weeks -- between November 5 to November 19 -- the number of child cases increased by 28%, according to the American Academy of Pediatrics and the Children's Hospital Association.
Children now represent nearly 12% of all COVID-19 cases in the country.