Aside from both a home and away date with AFC South rivals Tennessee, Jacksonville and Indianapolis, the Texans will face the teams from the NFC West and a few familiar AFC foes.
Outside the division, the Texans will welcome the Denver Broncos, Oakland Raiders, New England Patriots, St. Louis Rams and Seattle Seahawks to Reliant Stadium.
As for road games, Houston will face Kansas City, San Diego, Baltimore, Arizona and San Francisco on top of their division foes.
Seven of the Texans' 16 games in 2013 will be against playoff teams.
Full schedules with dates and times will be released closer to the start of next season.