It's the first Pro Bowl appearance for both players.
Running back Arian Foster and cornerback Johnathan Joseph were already named to the AFC squad, but Foster will miss the game due to a minor foot injury sustained in last week's loss to Baltimore.
The Pro Bowl is Jan. 29. The AFC squad will be led by Houston coach Gary Kubiak and his staff.
Myers is the first Texans offensive lineman to make the Pro Bowl. The Texans ranked second in rushing this season (153 yards per game). Smith finished with a career-high 6 1/2 sacks for the NFL's second-ranked defense.
Myers is replacing Pittsburgh's Maurkice Pouncey (ankle) and Smith will step in for New England's Andre Carter (knee).