Obama's only blemishes Friday were 13th-seeded Siena, which lost to fourth-seeded Purdue 72-64, and ninth-seeded Florida State, which fell to No. 8 seed Gonzaga 67-60.
The First Fan took a few chances on his bracket, which he filled out for ESPN for the second straight year. Siena was the second No. 13 seed he picked; he correctly chose Murray State to upset fourth-seeded Vanderbilt on Thursday.
Obama also had 12th-seeded Cornell topping No. 5 seed Temple -- and the Big Red came through with a 78-65 victory Friday.
Obama has his Final Four intact: Kansas, Kansas State, Kentucky and Villanova. He predicted North Carolina's national championship victory last year, when his bracket ranked 903,125th overall -- just above the 80th percentile in ESPN's online contest.
His biggest miss so far was Georgetown, which he predicted would reach the round of eight. The Hoyas, the No. 3 seed in the Midwest Regional, were stunned by 14th-seeded Ohio 97-83 on Thursday.
Marquette is the only other of his picks for the round of 16 that has lost. The sixth-seeded Golden Eagles were edged by No. 11 seed Washington 80-78 on Thursday night.