Constable Alan Rosen said property and cash were seized from the room in the 1500 block of College.
The game room takes in between $60,000 and $100,000 a day, authorities said.
HAPPENING NOW: Money laundering bust. Executing seven arrest warrants around greater Houston area. Seizure of property/cash underway at illegal game room. 1500 blk. College in City of South Houston. Media: @ConstableRosen will speak at scene. #hounews pic.twitter.com/QPpVBSKaDi— Constable Alan Rosen Harris County Pct. 1 (@Pct1Constable) June 25, 2019
Rosen tweeted video of deputies sawing the locks off 8-liner machines, sparks shooting everywhere.
The constable's office said this is the fourth time they've been at that game room in particular, and each time, the owners continued to build on to it, adding a bar and new machines.
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So far, five people have been arrested, but deputies are searching for two more.
"This is a game room that steals from people on fixed incomes. There's crime that happens in and around these places," Rosen said. "We've had people use Lone Star cards that they've traded off to gamble."
Rosen said they had received anonymous complaints about the game room, and those arrested are heavily involved in the gaming industry.
"We have $14 an hour workers who are being arrested. We're coming after the owners," Rosen said.
Rosen explained that the total dollar amount the game room has taken in could be in the millions.
So far, each suspect involved was arrested at his or her home.
"Oftentimes, people who are laundering money try to filter that money through legitimate businesses so that the money gets washed," Rosen explained.
This was a year-long investigation in conjunction with the Harris County District Attorney's Money Laundering Division.
Authorities plan to take every machine and clear the game room.