Bill Cosby's spokesman says the comedian's daughter, Ensa Cosby, has died in Massachusetts.
She was 44 years old.
There was no immediate word on a cause of death.
Spokesman Andrew Wyatt says: "Please keep the Cosby family in your prayers and give them peace at this time."
Bill Cosby has a court hearing scheduled this coming Monday and Tuesday ahead of his re-trial on sex assault charges in Montgomery County, Pa.