The fire began just after 4 a.m. at a home in 19000 block of Johnson Road near Tamina.
Authorities have identified the deceased children as 13-year-old Terrance (TJ) Mitchell, 6-year-old Kaila Mitchell and 5-year-old Kyle Mitchell.
The grandparents Bobby and Carrie Johnson, the mother of the children, her 10-year-old son Adrian Mitchell and the uncle Jarvis Johnson were injured.
Several first responders were injured as they attempted to rescue the family from the burning home.
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